Looking for online definition of skin-associated lymphoid tissues (SALT) in the Medical Dictionary? skin-associated lymphoid tissues (SALT) explanation free. provided skin with a unique collection of lymphoid cells, reticular cells, and organized Evidence in favor of the existence of skin-associated lymphoid tissues. Skin-associated lymphoid tissue (SALT) that consists of keratinocytes, Langerhans cells (LCs), dermal DCs, mast cells, macrophages, basophils, and T cells attest to the fact that skin is a potent immunologic organ .
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The recirculating properties of a subset of skin-seeking T lymphocytes equips them to migrate preferentially skin associated lymphoid tissue dermal vessels and the lymph nodes that drain the skin, creating a network of surveillance and communication that ensures that appropriate immune effectors and regulators are produced, and that threatening cutaneous pathogens are eliminated without compromise of skin function.
In nude mice thymosin-a1 appears to exert its effect at an early stage of T-cell differentiation and skin associated lymphoid tissue a T-cell subpopulation capable of producing IL-3 but not yet IL Thymosin-a1 and thymosin-b4 have been shown to increase the efficiency of Ag presentation by macrophages.
Only an extremely minute quantity of the substance can be used in each test since severe allergic reactions can occur. The scratch test is also used in the diagnosis of tuberculosis. Skin associated lymphoid tissue Pirquet's reaction, for example, tuberculin is used, and the local inflammatory reaction that skin associated lymphoid tissue is more marked in tuberculous persons than in normal ones.
In these tests, the substance under study is injected between the layers of skin. Intradermal tests are used for diagnosis of infectious diseases and determination of susceptibility to a disease or sensitivity to an allergen. In the intradermal test for tuberculosis, the Mantoux test, a purified protein derivative PPDprepared from tubercle bacilli, is injected.
In a positive result, the area becomes reddened or inflamed within 72 hours.
Skin-associated lymphoid tissues (SALT): origins and functions.
This indicates past or present infection with or exposure to the tubercle bacillus. An infection that has been present for at least 2 to 8 weeks will usually be revealed by the test.
The Schick test is used to determine susceptibility to diphtheria. A very small dose of diphtheria antitoxin is injected into the forearm.
Skin-associated lymphoid tissue.
In a positive reaction the area becomes red and remains so for about a week. If no reaction occurs, the person is immune to the disease.
The trichophytin test is sometimes used in diagnosing suspected cases of superficial fungus infection of the skin, such as ringworm. In the presence of infection by the fungus Trichophyton, an injection skin associated lymphoid tissue trichophytin, which is prepared from cultures of the fungus, will produce a reaction similar to the tuberculin reaction.
In patients who have been under long-term immunosuppressive therapy, the large majority of nonlymphoid malignancies arise within the skin, rather than other types of tissues. These data suggest that immune surveillance, once thought to be an immune defense operative in all somatic tissues, is a specialized immune function dedicated to the skin and mediated skin associated lymphoid tissue SALT.